Vitamin D

History

The historical narrative of Vitamin D3 unfolds in the 17th century, as physicians and scientists observed a compelling correlation between sunlight exposure and the prevention of rickets, a debilitating skeletal condition. The early 20th century marked a pivotal era when dedicated researchers like Sir Edward Mellanby and Sir Frederick Gowland Hopkins embarked on a quest to unveil the elusive "anti-rachitic factor." Mellanby's groundbreaking experiments in 1919, utilizing dogs and cod liver oil, yielded a critical breakthrough by establishing a tangible link between cod liver oil consumption and the prevention of rickets. This seminal work laid the foundation for subsequent investigations into the role of this enigmatic factor. Crucial developments, including the isolation of the active compound by researchers like Hopkins, shaped the early 20th-century landscape. The term "Vitamin D" was coined, and subsequent research delineated various forms, with Vitamin D3, or cholecalciferol, emerging as a significant variant synthesized in the skin upon exposure to sunlight.

Chemical Structure

At its core, Vitamin D refers to a group of fat-soluble secosteroids, with the two major forms being Vitamin D2 (ergocalciferol) and Vitamin D3 (cholecalciferol). Their unique molecular structures enable these compounds to regulate calcium and phosphorus levels in the body, playing a crucial role in maintaining bone health.

Vitamin D3 (Cholecalciferol)

Vitamin D2 (Ergocalciferol)

Variants

Exploring the Vitamin D family reveals a spectrum of related compounds. Vitamin D2, sourced from fungi and plants, contrasts with Vitamin D3, synthesized in the skin upon exposure to sunlight. Understanding these variants is key for tailoring nutritional recommendations to different dietary preferences and lifestyles.

Dosages

Name	Name	Dosage (μg)	Dosage (IU)
Vitamin D2	Ergocalciferol	30-300	1200-12000
Vitamin D3	Colecalciferol	10-100 μg	400-4000

Vitamin D3 is on average 3 times as potent as Vitamin D2

Toxicity

LD50 : 37mg/kg

Synergistic compounds

While Vitamin D relieves the arteries of calcium deposits, Vitamin K2 transports the calcium deposits to the bones. Vitamin K2 is also depleted during Vitamin D3 supplementation so it is a recommended combination.

Effects

Health benefits

• Decalcification of arteries
• Serotonin production and mood regulation
• Precursor to Testosteron synthesis
• Helps the immune sytem fight Covid

Risks

• Overdosing Vitamin D can lead to hypocalcemia, because of all the stored calcium deposits being released.
• Depletes Vitamin K, Vitamin K plays a crucial role in transporting calcium from the blood to the bones.

Subjective Effects

• Vitamin D has a mild relaxing effect and is thereby better taken in the evening

Attainability

Vitamin D can be found in various natural sources, primarily sourced from exposure to sunlight. When our skin is exposed to ultraviolet B (UVB) rays, it triggers the synthesis of Vitamin D3. Additionally, certain foods serve as rich dietary sources, including fatty fish such as salmon, mackerel, and tuna, as well as cod liver oil. Fortified foods, such as dairy products, orange juice, and cereals, are also common dietary sources, ensuring that individuals can meet their Vitamin D requirements even in regions with limited sunlight exposure. As the understanding of this essential vitamin continues to grow, a balanced approach that includes a combination of sunlight exposure and a well-rounded diet remains key to maintaining optimal Vitamin D levels and supporting overall health.

Legal Status

Vitamin D supplements are widely available, but their legal status can vary across regions. Navigating the regulations ensures that individuals can access these supplements safely and responsibly, keeping in mind their impact on health and well-being.

Product Suggestions

Curious about incorporating more Vitamin D into your life? From fortified foods to supplements, there's a variety of options. Popular products and recommendations cater to different preferences, making it easier for readers to find what suits them best.

References

1. REDIRECT Vitamin D