Vitamin D
History
The historical journey of Vitamin D3 began in the 17th century when physicians and scientists observed a peculiar correlation between sunlight exposure and the prevention of rickets, a debilitating skeletal condition. It wasn't until the early 20th century that dedicated researchers like Sir Edward Mellanby and Sir Frederick Gowland Hopkins embarked on a quest to identify the elusive "anti-rachitic factor." Mellanby's groundbreaking experiments in 1919, using dogs and cod liver oil, provided a critical breakthrough by demonstrating a tangible link between cod liver oil consumption and the prevention of rickets. This laid the foundation for further investigations into the role of this mysterious factor. The early 20th century witnessed a series of crucial developments, including the isolation of the active compound by researchers like Hopkins. The term "Vitamin D" was coined, and subsequent research differentiated between various forms, with Vitamin D3, or cholecalciferol, emerging as a significant variant synthesized in the skin upon exposure to sunlight.
Chemical Structure
At its core, Vitamin D refers to a group of fat-soluble secosteroids, with the two major forms being Vitamin D2 (ergocalciferol) and Vitamin D3 (cholecalciferol). The unique molecular structure enables these compounds to regulate calcium and phosphorus levels in the body, crucial for bone health.
Variants
Exploring the Vitamin D family reveals a spectrum of related compounds. Vitamin D2, sourced from fungi and plants, contrasts with Vitamin D3, synthesized in the skin upon exposure to sunlight. Understanding these variants is key for tailoring nutritional recommendations to different dietary preferences and lifestyles.
| Name | Name | Dosage |
|---|---|---|
| Vitamin D2 | Ergocalciferol | 30-300ug |
| Vitamin D3 | Colecalciferol | 10-100ug |
Vitamin D3 is on average 3 times as potent as Vitamin D2
Synergistic compounds
While Vitamin D relieves the arteries of calcium deposits, Vitamin K2 transports the calcium deposits to the bones. Vitamin K2 is also depleted during Vitamin D3 supplementation so it is a recommended combination.
Effects
Health benefits
- Decalcification of arteries
- Serotonin production and mood regulation
- Precursor to Testosteron synthesis
- Helps the immune sytem fight Covid
Risks
- Overdosing Vitamin D can lead to hypocalcemia, because of all the stored calcium deposits being released.
- Depletes Vitamin K2, Vitamin K2 plays a crucial role in transporting calcium from the blood to the bones.
Subjective Effects
- Vitamin D has a mild relaxing effect and is thereby better taken in the evening
Legal Status
Vitamin D supplements are widely available, but their legal status can vary across regions. Navigating the regulations ensures that individuals can access these supplements safely and responsibly, keeping in mind their impact on health and well-being.
Product Suggestions
Curious about incorporating more Vitamin D into your life? From fortified foods to supplements, there's a variety of options. Popular products and recommendations cater to different preferences, making it easier for readers to find what suits them best.